Assay Detail
Binding
CHEMBL763569
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.33 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264385 | — | — | 1 | 9.00 |
| CHEMBL81248 | — | — | 1 | 8.30 |
| CHEMBL81676 | — | — | 1 | 8.15 |
| CHEMBL77502 | LY-510929 | — | 1 | 8.05 |
| CHEMBL82034 | — | — | 1 | 7.92 |
| CHEMBL309882 | — | — | 1 | 7.75 |
| CHEMBL82602 | — | — | 1 | 7.72 |
| CHEMBL79426 | — | — | 1 | 7.17 |
| CHEMBL312717 | — | — | 1 | 7.16 |
| CHEMBL78529 | — | — | 1 | 7.12 |
| CHEMBL412371 | — | — | 1 | 6.41 |
| CHEMBL81592 | — | — | 1 | 6.26 |
| CHEMBL81208 | — | — | 1 | 6.08 |
| CHEMBL82193 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264385 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL81248 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL81676 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL77502 | LY-510929 | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL82034 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL309882 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL82602 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL79426 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL312717 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL78529 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL412371 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL81592 | — | EC50 | = | 549.0 | nM | 6.26 |
| CHEMBL81208 | — | EC50 | = | 833.0 | nM | 6.08 |
| CHEMBL82193 | — | EC50 | = | 2558.0 | nM | 5.59 |