Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL763572

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine Phosphatidylinositol 3-kinase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

17-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase
Dodge JA, Bryant HU, Kim J, Matter WF, Norman BH, Srinivasan U, Vlahos CJ, Sato M
Bioorg Med Chem Lett (1995) 5 : 1713 -1718
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 7.61 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL273832 1 9.30
CHEMBL428496 WORTMANNIN 1 8.38
CHEMBL13513 1 7.78
CHEMBL268976 1 7.27
CHEMBL13512 1 5.34
CHEMBL275536 1 -
CHEMBL871 ETIDRONIC ACID 4.0 1 -
CHEMBL295740 1 -
CHEMBL870 ALENDRONIC ACID 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL273832 IC50 = 0.5 nM 9.30
CHEMBL428496 WORTMANNIN IC50 = 4.2 nM 8.38
CHEMBL13513 IC50 = 16.7 nM 7.78
CHEMBL268976 IC50 = 54.0 nM 7.27
CHEMBL13512 IC50 = 4600.0 nM 5.34
CHEMBL275536 IC50 > 500.0 nM -
CHEMBL871 ETIDRONIC ACID IC50 > 50000.0 nM -
CHEMBL295740 IC50 > 32000.0 nM -
CHEMBL870 ALENDRONIC ACID IC50 > 50000.0 nM -