Assay Detail
Binding
CHEMBL763581
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Tested against S2-binding site of HIV-1 protease
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.55 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.64 |
| CHEMBL18067 | — | — | 1 | 8.52 |
| CHEMBL17600 | — | — | 1 | 8.27 |
| CHEMBL414648 | — | — | 1 | 8.05 |
| CHEMBL261340 | — | — | 1 | 7.96 |
| CHEMBL18068 | — | — | 1 | 7.94 |
| CHEMBL353815 | — | — | 1 | 7.92 |
| CHEMBL279326 | — | — | 1 | 7.88 |
| CHEMBL277801 | — | — | 1 | 7.65 |
| CHEMBL170576 | — | — | 1 | 7.52 |
| CHEMBL18031 | — | — | 1 | 7.28 |
| CHEMBL273317 | — | — | 1 | 7.12 |
| CHEMBL275389 | — | — | 1 | 6.85 |
| CHEMBL18389 | — | — | 1 | 6.80 |
| CHEMBL18253 | — | — | 1 | 6.77 |
| CHEMBL354897 | — | — | 1 | 6.16 |
| CHEMBL17704 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL18067 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL17600 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL414648 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL261340 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL18068 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL353815 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL279326 | — | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL277801 | — | IC50 | = | 22.3 | nM | 7.65 |
| CHEMBL170576 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL18031 | — | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL273317 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL275389 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL18389 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL18253 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL354897 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL17704 | — | IC50 | = | 1030.0 | nM | 5.99 |