Assay Detail
Binding
CHEMBL763582
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Tested for inhibitory activity against HIV protease enzyme
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design of HIV-1 protease inhibitors: replacement of two amides and a 10 pi-aromatic system by a fused bis-tetrahydrofuran.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.36 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83506 | — | — | 1 | 9.64 |
| CHEMBL315403 | — | — | 2 | 8.74 |
| CHEMBL83768 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83506 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL315403 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL83768 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL315403 | — | IC50 | = | 132.0 | nM | 6.88 |