Assay Detail
Binding
CHEMBL763585
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Tested for inhibitory concentration against HIV-1 protease
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 9.21 | 10.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17612 | — | — | 1 | 10.27 |
| CHEMBL75904 | — | — | 1 | 10.22 |
| CHEMBL310924 | — | — | 1 | 10.15 |
| CHEMBL73934 | — | — | 1 | 9.96 |
| CHEMBL307918 | — | — | 1 | 9.92 |
| CHEMBL309175 | — | — | 1 | 9.82 |
| CHEMBL306974 | — | — | 1 | 9.80 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.64 |
| CHEMBL432924 | — | — | 1 | 9.62 |
| CHEMBL74472 | — | — | 1 | 9.41 |
| CHEMBL76352 | — | — | 1 | 9.30 |
| CHEMBL306570 | — | — | 1 | 9.22 |
| CHEMBL75082 | — | — | 1 | 9.15 |
| CHEMBL307926 | — | — | 1 | 8.59 |
| CHEMBL265026 | — | — | 1 | 8.55 |
| CHEMBL74077 | — | — | 1 | 8.48 |
| CHEMBL312788 | — | — | 1 | 8.27 |
| CHEMBL306810 | — | — | 1 | 7.41 |
| CHEMBL418902 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17612 | — | IC50 | = | 0.054 | nM | 10.27 |
| CHEMBL75904 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL310924 | — | IC50 | = | 0.071 | nM | 10.15 |
| CHEMBL73934 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL307918 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL309175 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL306974 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL114 | SAQUINAVIR | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL432924 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL74472 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL76352 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL306570 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL75082 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL307926 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL265026 | — | IC50 | = | 2.83 | nM | 8.55 |
| CHEMBL74077 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL312788 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL306810 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL418902 | — | IC50 | = | 67.9 | nM | 7.17 |