Assay Detail
Binding
CHEMBL763643
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Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 9.46 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77788 | — | — | 1 | 10.72 |
| CHEMBL75684 | — | — | 1 | 10.38 |
| CHEMBL76382 | — | — | 1 | 10.34 |
| CHEMBL432348 | — | — | 1 | 10.16 |
| CHEMBL78237 | — | — | 1 | 10.04 |
| CHEMBL77358 | — | — | 1 | 9.84 |
| CHEMBL77745 | — | — | 1 | 9.47 |
| CHEMBL76635 | — | — | 1 | 8.92 |
| CHEMBL77999 | — | — | 1 | 8.81 |
| CHEMBL76257 | — | — | 1 | 8.70 |
| CHEMBL78238 | — | — | 1 | 8.64 |
| CHEMBL80258 | — | — | 1 | 8.56 |
| CHEMBL306320 | — | — | 1 | 8.46 |
| CHEMBL77177 | — | — | 1 | - |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL431962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77788 | — | Ki | = | 0.019 | nM | 10.72 |
| CHEMBL75684 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL76382 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL432348 | — | Ki | = | 0.069 | nM | 10.16 |
| CHEMBL78237 | — | Ki | = | 0.092 | nM | 10.04 |
| CHEMBL77358 | — | Ki | = | 0.146 | nM | 9.84 |
| CHEMBL77745 | — | Ki | = | 0.336 | nM | 9.47 |
| CHEMBL76635 | — | Ki | = | 1.197 | nM | 8.92 |
| CHEMBL77999 | — | Ki | = | 1.559 | nM | 8.81 |
| CHEMBL76257 | — | Ki | = | 2.02 | nM | 8.70 |
| CHEMBL78238 | — | Ki | = | 2.31 | nM | 8.64 |
| CHEMBL80258 | — | Ki | = | 2.73 | nM | 8.56 |
| CHEMBL306320 | — | Ki | = | 3.455 | nM | 8.46 |
| CHEMBL77177 | — | Ki | > | 5.0 | nM | - |
| CHEMBL63 | ROLIPRAM | Ki | = | 0.0023 | nM | - |
| CHEMBL431962 | — | Ki | > | 5.0 | nM | - |