Assay Detail
Binding
CHEMBL763673
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Phosphodiesterase 5 from human
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and cyclic GMP phosphodiesterase inhibitory activity of a series of 6-phenylpyrazolo[3,4-d]pyrimidones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 8.12 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298295 | — | — | 1 | 10.00 |
| CHEMBL42988 | — | — | 1 | 9.70 |
| CHEMBL43443 | — | — | 1 | 9.10 |
| CHEMBL297864 | — | — | 1 | 9.00 |
| CHEMBL288061 | — | — | 1 | 9.00 |
| CHEMBL298478 | — | — | 1 | 8.82 |
| CHEMBL296294 | — | — | 1 | 8.77 |
| CHEMBL295329 | — | — | 1 | 8.70 |
| CHEMBL43862 | — | — | 1 | 8.70 |
| CHEMBL416267 | — | — | 1 | 8.70 |
| CHEMBL46714 | — | — | 1 | 8.70 |
| CHEMBL290694 | — | — | 1 | 8.70 |
| CHEMBL46771 | — | — | 1 | 8.70 |
| CHEMBL291178 | — | — | 1 | 8.70 |
| CHEMBL42886 | — | — | 1 | 8.70 |
| CHEMBL45039 | — | — | 1 | 8.60 |
| CHEMBL43205 | — | — | 1 | 8.60 |
| CHEMBL296071 | — | — | 1 | 8.60 |
| CHEMBL45367 | — | — | 1 | 8.52 |
| CHEMBL289701 | — | — | 1 | 8.52 |
| CHEMBL297763 | — | — | 1 | 8.52 |
| CHEMBL43225 | — | — | 1 | 8.52 |
| CHEMBL295614 | — | — | 1 | 8.52 |
| CHEMBL42272 | — | — | 1 | 8.52 |
| CHEMBL46621 | — | — | 1 | 8.46 |
| CHEMBL298294 | — | — | 1 | 8.40 |
| CHEMBL298282 | — | — | 1 | 8.40 |
| CHEMBL290402 | — | — | 1 | 8.40 |
| CHEMBL42776 | — | — | 1 | 8.40 |
| CHEMBL42779 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298295 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL42988 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL43443 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL297864 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL288061 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL298478 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL296294 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL43862 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL416267 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL46714 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL290694 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL291178 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL295329 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL42886 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL46771 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL45039 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL296071 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL43205 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL289701 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL42272 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL295614 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL43225 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL297763 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL45367 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL46621 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL298294 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL42779 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL42776 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL298282 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL290402 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL295224 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL289344 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL41004 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL42172 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL439923 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL43320 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL42680 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL295613 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL43665 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL44467 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL46831 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL47108 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL46416 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL46693 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL43795 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL42435 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL42570 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL42796 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL46639 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL42713 | — | IC50 | = | 80.0 | nM | 7.10 |