Assay Detail
Functional
CHEMBL763687
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Parasite growth in chloroquine-sensitive Plasmodium falciparum K1
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.18 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343728 | — | — | 1 | 7.23 |
| CHEMBL143522 | — | — | 1 | 7.17 |
| CHEMBL139984 | — | — | 1 | 7.03 |
| CHEMBL342499 | — | — | 1 | 6.70 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.46 |
| CHEMBL423184 | — | — | 1 | 6.38 |
| CHEMBL143439 | — | — | 1 | 6.06 |
| CHEMBL44789 | — | — | 1 | 6.00 |
| CHEMBL143042 | — | — | 1 | 5.96 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | — | 1 | 5.89 |
| CHEMBL344599 | — | — | 1 | 5.85 |
| CHEMBL143177 | — | — | 1 | 5.37 |
| CHEMBL143331 | — | — | 1 | 5.31 |
| CHEMBL142884 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343728 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL143522 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL139984 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL342499 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL423184 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL143439 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL44789 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL143042 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1236 | DESETHYLCHLOROQUINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL344599 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL143177 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL143331 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL142884 | — | IC50 | = | 8000.0 | nM | 5.10 |