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Assay Detail

CHEMBL763754

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Binding
Inhibition of HIV-1 protease
ChEMBL ↗
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 protease (CHEMBL243) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.
Young SD, Payne LS, Thompson WJ, Gaffin N, Lyle TA, Britcher SF, Graham SL, Schultz TH, Deana AA, Darke PL.
J Med Chem (1992) 35 : 1702 -1709
PubMed 1588552 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 9.36 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49768 — — 1 10.15
CHEMBL297294 — — 1 10.10
CHEMBL44489 — — 1 10.00
CHEMBL297066 — — 1 9.89
CHEMBL298316 — — 1 9.80
CHEMBL291196 — — 1 9.80
CHEMBL47610 — — 1 9.77
CHEMBL295471 — — 1 9.77
CHEMBL46114 — — 1 9.77
CHEMBL295530 — — 1 9.77
CHEMBL297189 — — 1 9.68
CHEMBL295357 — — 1 9.66
CHEMBL47480 — — 1 9.64
CHEMBL265514 — — 1 9.64
CHEMBL296115 — — 1 9.64
CHEMBL296484 — — 1 9.59
CHEMBL297620 — — 1 9.57
CHEMBL295904 — — 1 9.57
CHEMBL295924 — — 1 9.54
CHEMBL265516 — — 1 9.54
CHEMBL296493 — — 1 9.51
CHEMBL291195 — — 1 9.44
CHEMBL289195 — — 1 9.38
CHEMBL49544 — — 1 9.37
CHEMBL298788 — — 1 9.37
CHEMBL296137 — — 1 9.36
CHEMBL47465 — — 1 9.29
CHEMBL299821 — — 1 9.23
CHEMBL47514 — — 1 9.22
CHEMBL416814 — — 1 9.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49768 — IC50 = 0.07 nM 10.15
CHEMBL297294 — IC50 = 0.08 nM 10.10
CHEMBL44489 — IC50 = 0.1 nM 10.00
CHEMBL297066 — IC50 = 0.13 nM 9.89
CHEMBL298316 — IC50 = 0.16 nM 9.80
CHEMBL291196 — IC50 = 0.16 nM 9.80
CHEMBL47610 — IC50 = 0.17 nM 9.77
CHEMBL295471 — IC50 = 0.17 nM 9.77
CHEMBL46114 — IC50 = 0.17 nM 9.77
CHEMBL295530 — IC50 = 0.17 nM 9.77
CHEMBL297189 — IC50 = 0.21 nM 9.68
CHEMBL295357 — IC50 = 0.22 nM 9.66
CHEMBL47480 — IC50 = 0.23 nM 9.64
CHEMBL265514 — IC50 = 0.23 nM 9.64
CHEMBL296115 — IC50 = 0.23 nM 9.64
CHEMBL296484 — IC50 = 0.26 nM 9.59
CHEMBL297620 — IC50 = 0.27 nM 9.57
CHEMBL295904 — IC50 = 0.27 nM 9.57
CHEMBL295924 — IC50 = 0.29 nM 9.54
CHEMBL265516 — IC50 = 0.29 nM 9.54
CHEMBL296493 — IC50 = 0.31 nM 9.51
CHEMBL291195 — IC50 = 0.36 nM 9.44
CHEMBL289195 — IC50 = 0.42 nM 9.38
CHEMBL49544 — IC50 = 0.43 nM 9.37
CHEMBL298788 — IC50 = 0.43 nM 9.37
CHEMBL296137 — IC50 = 0.44 nM 9.36
CHEMBL47465 — IC50 = 0.51 nM 9.29
CHEMBL299821 — IC50 = 0.59 nM 9.23
CHEMBL47514 — IC50 = 0.6 nM 9.22
CHEMBL416814 — IC50 = 0.6 nM 9.22
CHEMBL296855 — IC50 = 0.72 nM 9.14
CHEMBL433072 — IC50 = 0.91 nM 9.04
CHEMBL45928 — IC50 = 1.0 nM 9.00
CHEMBL295777 — IC50 = 1.15 nM 8.94
CHEMBL295345 — IC50 = 1.2 nM 8.92
CHEMBL46061 — IC50 = 1.4 nM 8.85
CHEMBL45953 — IC50 = 6.0 nM 8.22
CHEMBL297633 — IC50 = 34.7 nM 7.46
CHEMBL297349 — IC50 = 62.7 nM 7.20
CHEMBL48281 — IC50 > 3000.0 nM -