Assay Detail
Functional
CHEMBL763799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell proliferation of human pancreas PAXF736 tumor xenograft in colony forming assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PAXF736 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, cytotoxicity, and antitumor activity of copper(II) and iron(II) complexes of (4)N-azabicyclo[3.2.2]nonane thiosemicarbazones derived from acyl diazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.70 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307750 | N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | 7.82 |
| CHEMBL307351 | — | — | 1 | 7.57 |
| CHEMBL68043 | — | — | 1 | - |
| CHEMBL71931 | N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | - |
| CHEMBL303030 | N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | — | 1 | - |
| CHEMBL68899 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307750 | N-[(1E)-1-(6-methylpyrimidin-4-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL307351 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL68043 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL71931 | N-[(1E)-1-(3-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | < | 0.1 | nM | - |
| CHEMBL303030 | N-[(1E)-1-(5-methylpyrazin-2-yl)ethylidene]-3-azabicyclo[3.2.2]nonane-3-carbohydrazonothioic acid.chloro Cu(II)complex | IC50 | < | 10.0 | nM | - |
| CHEMBL68899 | — | IC50 | < | 0.1 | nM | - |