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Assay Detail

CHEMBL763843

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity of alpha-ketoesters towards papain at pH 6.0
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Papain (CHEMBL4779)
Type SINGLE PROTEIN
Organism Carica papaya

Publication

Peptide alpha-keto ester, alpha-keto amide, and alpha-keto acid inhibitors of calpains and other cysteine proteases.
Li Z, Patil GS, Golubski ZE, Hori H, Tehrani K, Foreman JE, Eveleth DD, Bartus RT, Powers JC.
J Med Chem (1993) 36 : 3472 -3480
PubMed 8230139 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 4.49 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL117023 1 5.16
CHEMBL333388 1 5.00
CHEMBL118908 1 4.87
CHEMBL117450 1 4.82
CHEMBL3142933 1 4.82
CHEMBL117336 1 4.42
CHEMBL118025 1 4.42
CHEMBL115630 1 4.40
CHEMBL324834 1 4.35
CHEMBL420872 1 4.35
CHEMBL411658 1 4.12
CHEMBL325147 1 4.03
CHEMBL444594 1 4.03
CHEMBL331850 1 4.00
CHEMBL117891 1 -
CHEMBL325401 1 -
CHEMBL117905 1 -
CHEMBL117255 1 -
CHEMBL116358 1 -
CHEMBL117232 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL117023 Ki = 7000.0 nM 5.16
CHEMBL333388 Ki = 10000.0 nM 5.00
CHEMBL118908 Ki = 13500.0 nM 4.87
CHEMBL117450 Ki = 15000.0 nM 4.82
CHEMBL3142933 Ki = 15000.0 nM 4.82
CHEMBL117336 Ki = 38000.0 nM 4.42
CHEMBL118025 Ki = 38000.0 nM 4.42
CHEMBL115630 Ki = 40000.0 nM 4.40
CHEMBL324834 Ki = 45000.0 nM 4.35
CHEMBL420872 Ki = 45000.0 nM 4.35
CHEMBL411658 Ki = 75000.0 nM 4.12
CHEMBL325147 Ki = 93000.0 nM 4.03
CHEMBL444594 Ki = 93000.0 nM 4.03
CHEMBL331850 Ki = 100000.0 nM 4.00
CHEMBL117891 Ki = 150000.0 nM -
CHEMBL325401 Ki = 190000.0 nM -
CHEMBL117905 Ki = 220000.0 nM -
CHEMBL117255 Ki = 140000.0 nM -
CHEMBL116358 Ki = 190000.0 nM -
CHEMBL117232 Ki = 150000.0 nM -