Assay Detail
Functional
CHEMBL763845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro effective concentration for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected KRP-297 cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | KRP-297 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 6.13 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118329 | — | — | 1 | 7.70 |
| CHEMBL118939 | — | — | 1 | 7.40 |
| CHEMBL120009 | — | — | 1 | 7.40 |
| CHEMBL116540 | — | — | 1 | 7.37 |
| CHEMBL107789 | — | — | 1 | 7.22 |
| CHEMBL122070 | — | — | 1 | 7.05 |
| CHEMBL119791 | — | — | 1 | 6.96 |
| CHEMBL120243 | — | — | 1 | 6.89 |
| CHEMBL119911 | — | — | 1 | 6.64 |
| CHEMBL120456 | — | — | 1 | 6.62 |
| CHEMBL120246 | — | — | 1 | 6.54 |
| CHEMBL331469 | — | — | 1 | 6.50 |
| CHEMBL332465 | — | — | 1 | 6.44 |
| CHEMBL116947 | — | — | 1 | 6.40 |
| CHEMBL120748 | — | — | 1 | 6.17 |
| CHEMBL120611 | — | — | 1 | 6.13 |
| CHEMBL262558 | — | — | 1 | 6.07 |
| CHEMBL331206 | — | — | 1 | 6.00 |
| CHEMBL24458 | — | — | 1 | 6.00 |
| CHEMBL120676 | — | — | 1 | 5.92 |
| CHEMBL118413 | — | — | 1 | 5.89 |
| CHEMBL120444 | — | — | 1 | 5.82 |
| CHEMBL120744 | — | — | 1 | 5.80 |
| CHEMBL325723 | — | — | 1 | 5.80 |
| CHEMBL331464 | — | — | 1 | 5.75 |
| CHEMBL122009 | — | — | 1 | 5.66 |
| CHEMBL118198 | — | — | 1 | 5.64 |
| CHEMBL118483 | — | — | 1 | 5.57 |
| CHEMBL333778 | — | — | 1 | 5.55 |
| CHEMBL331557 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118329 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL118939 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL120009 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL116540 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL107789 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL122070 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL119791 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL120243 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL119911 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL120456 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL120246 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL331469 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL332465 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL116947 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL120748 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL120611 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL262558 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL331206 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL24458 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL120676 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL118413 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL120444 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL120744 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL325723 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL331464 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL122009 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL118198 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL118483 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL333778 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL331557 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL118492 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL119682 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL118976 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL118279 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL120620 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL326777 | — | EC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL672 | FENOFIBRATE | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | > | 78000.0 | nM | - |