Assay Detail
Binding
CHEMBL763873
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Tested for inhibition of HIV protease
19
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 9.08 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112563 | — | — | 1 | 10.74 |
| CHEMBL2092978 | — | — | 4 | 10.52 |
| CHEMBL2111768 | — | — | 2 | 10.49 |
| CHEMBL2111769 | — | — | 1 | 10.40 |
| CHEMBL2092977 | — | — | 1 | 10.00 |
| CHEMBL2111770 | — | — | 1 | 9.92 |
| CHEMBL20846 | — | — | 1 | 8.52 |
| CHEMBL326566 | — | — | 1 | 8.22 |
| CHEMBL21281 | — | — | 1 | 8.10 |
| CHEMBL115743 | — | — | 1 | 7.77 |
| CHEMBL137138 | — | — | 1 | 7.46 |
| CHEMBL22164 | — | — | 1 | 7.42 |
| CHEMBL1465 | PHENPROCOUMON | 4.0 | 1 | 6.00 |
| CHEMBL2062136 | — | — | 1 | - |
| CHEMBL2112565 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112563 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL2092978 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL2111768 | — | Ki | = | 0.032 | nM | 10.49 |
| CHEMBL2111769 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL2092978 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL2092977 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2092978 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL2111770 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL2111768 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL2092978 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL20846 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL326566 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL21281 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL115743 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL137138 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL22164 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL1465 | PHENPROCOUMON | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL2112565 | — | Ki | = | 0.007 | nM | - |
| CHEMBL2062136 | — | Ki | < | 1.0 | nM | - |