Assay Detail
Binding
CHEMBL763874
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Compound was tested for inhibition of HIV protease triple mutant (Q7K/L33I/L63I)
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL21188 | — | — | 1 | 9.00 |
| CHEMBL222559 | TIPRANAVIR | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL21188 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL222559 | TIPRANAVIR | Ki | = | 0.008 | nM | - |
| CHEMBL222559 | TIPRANAVIR | Ki | < | 1.0 | nM | - |