Assay Detail
Functional
CHEMBL763903
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Inhibition of AII(50 nM) induced intracellular [Ca2+] increase in PLC-PRF cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PLC-PRF |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Comparison of 3D structures and AT(1) binding properties of pyrazolidine-3,5-diones and tetrahydropyridazine-3,6-diones with parent antihypertensive drug irbesartan.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.75 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.40 |
| CHEMBL358359 | — | — | 1 | 8.05 |
| CHEMBL315444 | — | — | 1 | 7.55 |
| CHEMBL146275 | — | — | 1 | 6.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL358359 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL315444 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL146275 | — | IC50 | = | 102.0 | nM | 6.99 |