Assay Detail
Binding
CHEMBL763944
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Displacement of [3H]rolipram binding to guinea pig brain membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Quaternary substituted PDE4 inhibitors I: the synthesis and in vitro evaluation of a novel series of oxindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.13 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32442 | CDP840 | — | 1 | 7.22 |
| CHEMBL297296 | — | — | 1 | 6.70 |
| CHEMBL49351 | — | — | 1 | 5.62 |
| CHEMBL300959 | — | — | 1 | 5.58 |
| CHEMBL301351 | — | — | 1 | 5.55 |
| CHEMBL300038 | — | — | 1 | - |
| CHEMBL301366 | — | — | 1 | - |
| CHEMBL52224 | — | — | 1 | - |
| CHEMBL430948 | — | — | 1 | - |
| CHEMBL48221 | — | — | 1 | - |
| CHEMBL296824 | — | — | 1 | - |
| CHEMBL300427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32442 | CDP840 | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL297296 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL49351 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL300959 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL301351 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL300038 | — | Ki | > | 3700.0 | nM | - |
| CHEMBL301366 | — | Ki | > | 3700.0 | nM | - |
| CHEMBL52224 | — | Ki | > | 3700.0 | nM | - |
| CHEMBL430948 | — | Ki | > | 3700.0 | nM | - |
| CHEMBL48221 | — | Ki | > | 3700.0 | nM | - |
| CHEMBL296824 | — | Ki | > | 3700.0 | nM | - |
| CHEMBL300427 | — | Ki | > | 3700.0 | nM | - |