Assay Detail
Binding
CHEMBL763947
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Inhibition of Phosphodiesterase 4 from human neutrophils
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The synthesis and biological evaluation of a novel series of phthalazine PDE4 inhibitors I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.36 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.00 |
| CHEMBL74404 | — | — | 1 | 8.00 |
| CHEMBL309341 | — | — | 1 | 7.72 |
| CHEMBL308407 | — | — | 1 | 7.52 |
| CHEMBL419814 | — | — | 1 | 7.52 |
| CHEMBL308158 | — | — | 1 | 7.41 |
| CHEMBL72362 | — | — | 1 | 7.38 |
| CHEMBL70391 | — | — | 1 | 7.28 |
| CHEMBL74631 | — | — | 1 | 7.24 |
| CHEMBL70903 | — | — | 1 | 7.23 |
| CHEMBL73640 | — | — | 1 | 6.82 |
| CHEMBL303880 | — | — | 1 | 6.73 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL74404 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL309341 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL308407 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL419814 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL308158 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL72362 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL70391 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL74631 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL70903 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL73640 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL303880 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1680.0 | nM | 5.78 |