Assay Detail
Binding
CHEMBL763949
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Inhibition of human Phosphodiesterase 4
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.47 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.00 |
| CHEMBL79902 | — | — | 1 | 8.40 |
| CHEMBL79471 | — | — | 1 | 7.85 |
| CHEMBL310387 | — | — | 1 | 7.43 |
| CHEMBL79535 | — | — | 1 | 7.42 |
| CHEMBL80107 | — | — | 1 | 7.32 |
| CHEMBL70391 | — | — | 1 | 7.28 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.14 |
| CHEMBL312375 | — | — | 1 | 7.03 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL79902 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL79471 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL310387 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL79535 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL80107 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL70391 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL312375 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1680.0 | nM | 5.78 |