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Assay Detail

CHEMBL764126

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human Prostanoid IP receptor in CHO cells.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Prostacyclin receptor (CHEMBL1995)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of a highly selective EP2-receptor agonist.
Tani K, Naganawa A, Ishida A, Egashira H, Sagawa K, Harada H, Ogawa M, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M.
Bioorg Med Chem Lett (2001) 11 : 2025 -2028
PubMed 11454472 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.44 6.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL495 ALPROSTADIL 4.0 1 6.82
CHEMBL64663 1 6.06
CHEMBL293242 1 -
CHEMBL432522 1 -
CHEMBL64483 1 -
CHEMBL294585 1 -
CHEMBL433249 1 -
CHEMBL303763 1 -
CHEMBL304225 1 -
CHEMBL64804 1 -
CHEMBL62987 1 -
CHEMBL64358 1 -
CHEMBL64246 1 -
CHEMBL62885 1 -
CHEMBL293697 1 -
CHEMBL64423 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL495 ALPROSTADIL Ki = 150.0 nM 6.82
CHEMBL64663 Ki = 870.0 nM 6.06
CHEMBL293242 Ki > 0.0001 nM -
CHEMBL432522 Ki > 10000.0 nM -
CHEMBL64483 Ki > 10000.0 nM -
CHEMBL294585 Ki > 10000.0 nM -
CHEMBL433249 Ki > 10000.0 nM -
CHEMBL303763 Ki > 10000.0 nM -
CHEMBL304225 Ki > 10000.0 nM -
CHEMBL64804 Ki > 10000.0 nM -
CHEMBL62987 Ki > 0.0001 nM -
CHEMBL64358 Ki > 10000.0 nM -
CHEMBL64246 Ki > 10000.0 nM -
CHEMBL62885 Ki > 10000.0 nM -
CHEMBL293697 Ki > 10000.0 nM -
CHEMBL64423 Ki > 0.0001 nM -