Assay Detail
Binding
CHEMBL764128
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Affinity for human Prostanoid IP receptor expressed in CHO cells
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.18 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495 | ALPROSTADIL | 4.0 | 2 | 6.82 |
| CHEMBL64187 | — | — | 1 | 6.12 |
| CHEMBL294108 | — | — | 1 | 6.06 |
| CHEMBL62868 | — | — | 1 | 6.04 |
| CHEMBL60555 | — | — | 1 | 5.85 |
| CHEMBL63061 | — | — | 1 | - |
| CHEMBL291630 | — | — | 1 | - |
| CHEMBL439934 | — | — | 1 | - |
| CHEMBL64188 | — | — | 1 | - |
| CHEMBL64072 | — | — | 1 | - |
| CHEMBL292964 | — | — | 1 | - |
| CHEMBL293647 | — | — | 1 | - |
| CHEMBL60894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495 | ALPROSTADIL | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL64187 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL294108 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL62868 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL60555 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL63061 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL291630 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL439934 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL64188 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL64072 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL292964 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL293647 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL60894 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL495 | ALPROSTADIL | Ki | > | 10000.0 | nM | - |