Assay Detail
Binding
CHEMBL764177
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Binding affinity towards Human Purine Nucleoside Phosphorylase was reported
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Urine |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.01 | 9.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435085 | — | — | 1 | 9.79 |
| CHEMBL473922 | — | — | 1 | 9.27 |
| CHEMBL269864 | ULODESINE | 2.0 | 1 | 8.96 |
| CHEMBL2311112 | — | — | 1 | 8.85 |
| CHEMBL357062 | — | — | 1 | 8.70 |
| CHEMBL218291 | FORODESINE | 4.0 | 1 | 8.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435085 | — | Ki | = | 0.163 | nM | 9.79 |
| CHEMBL473922 | — | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL269864 | ULODESINE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2311112 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL357062 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL218291 | FORODESINE | Ki | = | 3.3 | nM | 8.48 |