Assay Detail
Binding
CHEMBL764269
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV-1 protease
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
An orally bioavailable pyrrolinone inhibitor of HIV-1 protease: computational analysis and X-ray crystal structure of the enzyme complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.61 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062160 | — | — | 1 | 10.52 |
| CHEMBL298316 | — | — | 1 | 9.80 |
| CHEMBL296115 | — | — | 1 | 9.52 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.44 |
| CHEMBL289195 | — | — | 1 | 9.22 |
| CHEMBL293808 | — | — | 1 | 8.70 |
| CHEMBL430445 | — | — | 1 | 8.22 |
| CHEMBL108960 | — | — | 1 | 8.15 |
| CHEMBL70140 | — | — | 1 | 8.00 |
| CHEMBL291974 | — | — | 1 | 7.92 |
| CHEMBL2062145 | — | — | 1 | 7.07 |
| CHEMBL606565 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062160 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL298316 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL296115 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5483011 | INDINAVIR | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL289195 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL293808 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL430445 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL108960 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL70140 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL291974 | — | IC50 | = | 11.9 | nM | 7.92 |
| CHEMBL2062145 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL606565 | — | IC50 | = | 186.0 | nM | 6.73 |