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Assay Detail

CHEMBL764369

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of plasmin with Val-L-Leu-L-lysine-p-nitroanilide as substrate
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Plasminogen (CHEMBL2957)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Inhibition studies of some serine and thiol proteinases by new leupeptin analogues.
McConnell RM, York JL, Frizzell D, Ezell C.
J Med Chem (1993) 36 : 1084 -1089
PubMed 8478905 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.89 5.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2373041 1 5.66
CHEMBL2373053 1 5.44
CHEMBL191881 LEUPEPTIN 1 5.43
CHEMBL2373064 1 5.25
CHEMBL2373060 1 5.11
CHEMBL2373046 1 4.96
CHEMBL2373045 1 4.89
CHEMBL2373049 1 4.77
CHEMBL2373051 1 4.75
CHEMBL2373062 1 4.19
CHEMBL2373047 1 4.17
CHEMBL2373044 1 4.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2373041 IC50 = 2200.0 nM 5.66
CHEMBL2373053 IC50 = 3600.0 nM 5.44
CHEMBL191881 LEUPEPTIN IC50 = 3700.0 nM 5.43
CHEMBL2373064 IC50 = 5600.0 nM 5.25
CHEMBL2373060 IC50 = 7700.0 nM 5.11
CHEMBL2373046 IC50 = 11000.0 nM 4.96
CHEMBL2373045 IC50 = 13000.0 nM 4.89
CHEMBL2373049 IC50 = 17000.0 nM 4.77
CHEMBL2373051 IC50 = 18000.0 nM 4.75
CHEMBL2373062 IC50 = 65000.0 nM 4.19
CHEMBL2373047 IC50 = 67000.0 nM 4.17
CHEMBL2373044 IC50 = 78000.0 nM 4.11