Assay Detail
Functional
CHEMBL764404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation of peroxisome proliferator activated receptor gamma
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 6.20 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320553 | — | — | 1 | 7.36 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 7.05 |
| CHEMBL331798 | — | — | 1 | 6.51 |
| CHEMBL116043 | — | — | 1 | 6.47 |
| CHEMBL408 | TROGLITAZONE | 4.0 | 1 | 6.27 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.23 |
| CHEMBL326947 | — | — | 1 | 5.52 |
| CHEMBL111841 | — | — | 1 | 5.25 |
| CHEMBL268513 | — | — | 1 | 5.15 |
| CHEMBL115448 | — | — | 1 | - |
| CHEMBL115310 | — | — | 1 | - |
| CHEMBL113006 | — | — | 1 | - |
| CHEMBL420314 | — | — | 1 | - |
| CHEMBL113587 | — | — | 1 | - |
| CHEMBL275682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320553 | — | EC50 | = | 43.65 | nM | 7.36 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL331798 | — | EC50 | = | 309.03 | nM | 6.51 |
| CHEMBL116043 | — | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL408 | TROGLITAZONE | EC50 | = | 537.03 | nM | 6.27 |
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 588.84 | nM | 6.23 |
| CHEMBL326947 | — | EC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL111841 | — | EC50 | = | 5623.41 | nM | 5.25 |
| CHEMBL268513 | — | EC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL115448 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL115310 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL113006 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL420314 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL113587 | — | EC50 | < | 10000.0 | nM | - |
| CHEMBL275682 | — | EC50 | < | 10000.0 | nM | - |