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Assay Detail

CHEMBL764525

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Parallel synthesis and anti-malarial activity of a sulfonamide library.
Ryckebusch A, Déprez-Poulain R, Debreu-Fontaine MA, Vandaele R, Mouray E, Grellier P, Sergheraert C.
Bioorg Med Chem Lett (2002) 12 : 2595 -2598
PubMed 12182868 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.70 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL89732 1 8.92
CHEMBL328265 1 8.13
CHEMBL315975 1 8.07
CHEMBL87431 1 8.01
CHEMBL431084 1 7.99
CHEMBL315677 1 7.95
CHEMBL87198 1 7.83
CHEMBL87110 1 7.82
CHEMBL89645 1 7.78
CHEMBL422953 1 7.78
CHEMBL86727 1 7.77
CHEMBL89242 1 7.73
CHEMBL90157 1 7.64
CHEMBL312850 1 7.59
CHEMBL89861 1 7.58
CHEMBL86622 1 7.16
CHEMBL86607 1 6.95
CHEMBL76 CHLOROQUINE 4.0 1 6.90
CHEMBL86739 1 6.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL89732 IC50 = 1.2 nM 8.92
CHEMBL328265 IC50 = 7.4 nM 8.13
CHEMBL315975 IC50 = 8.5 nM 8.07
CHEMBL87431 IC50 = 9.73 nM 8.01
CHEMBL431084 IC50 = 10.2 nM 7.99
CHEMBL315677 IC50 = 11.2 nM 7.95
CHEMBL87198 IC50 = 14.9 nM 7.83
CHEMBL87110 IC50 = 15.0 nM 7.82
CHEMBL89645 IC50 = 16.7 nM 7.78
CHEMBL422953 IC50 = 16.6 nM 7.78
CHEMBL86727 IC50 = 16.9 nM 7.77
CHEMBL89242 IC50 = 18.7 nM 7.73
CHEMBL90157 IC50 = 23.0 nM 7.64
CHEMBL312850 IC50 = 25.6 nM 7.59
CHEMBL89861 IC50 = 26.0 nM 7.58
CHEMBL86622 IC50 = 69.0 nM 7.16
CHEMBL86607 IC50 = 112.0 nM 6.95
CHEMBL76 CHLOROQUINE IC50 = 126.0 nM 6.90
CHEMBL86739 IC50 = 167.0 nM 6.78