Assay Detail
Binding
CHEMBL764539
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Inhibition of phosphodiesterase 4
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.80 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.52 |
| CHEMBL544766 | — | — | 1 | 9.52 |
| CHEMBL554636 | — | — | 1 | 9.52 |
| CHEMBL553502 | — | — | 1 | 9.40 |
| CHEMBL542299 | — | — | 1 | 9.30 |
| CHEMBL556179 | — | — | 1 | 9.22 |
| CHEMBL536568 | — | — | 1 | 9.15 |
| CHEMBL543016 | — | — | 1 | 9.15 |
| CHEMBL539265 | — | — | 1 | 9.00 |
| CHEMBL542650 | — | — | 1 | 8.70 |
| CHEMBL545700 | — | — | 1 | 8.52 |
| CHEMBL553278 | — | — | 1 | 7.16 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL544766 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL554636 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL553502 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL542299 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL556179 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL536568 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL543016 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL539265 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL542650 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL545700 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL553278 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 500.0 | nM | 6.30 |