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Assay Detail

CHEMBL764540

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Binding
Inhibition of phosphodiesterase 4 at 1 uM cAMP
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Phosphodiesterase 4 (CHEMBL2093863)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.
Bourguignon JJ, Désaubry L, Raboisson P, Wermuth CG, Lugnier C.
J Med Chem (1997) 40 : 1768 -1770
PubMed 9191951 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.61 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL299650 1 7.40
CHEMBL51315 1 6.70
CHEMBL52284 1 6.30
CHEMBL52231 1 6.12
CHEMBL299203 1 5.75
CHEMBL50040 1 5.34
CHEMBL301502 1 4.96
CHEMBL299959 1 4.96
CHEMBL542617 1 4.28
CHEMBL295315 1 4.27
CHEMBL266094 9-BENZYL-9H-ADENINE 1 -
CHEMBL544491 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL299650 IC50 = 40.0 nM 7.40
CHEMBL51315 IC50 = 200.0 nM 6.70
CHEMBL52284 IC50 = 500.0 nM 6.30
CHEMBL52231 IC50 = 750.0 nM 6.12
CHEMBL299203 IC50 = 1800.0 nM 5.75
CHEMBL50040 IC50 = 4600.0 nM 5.34
CHEMBL301502 IC50 = 11000.0 nM 4.96
CHEMBL299959 IC50 = 11000.0 nM 4.96
CHEMBL542617 IC50 = 53000.0 nM 4.28
CHEMBL295315 IC50 = 54000.0 nM 4.27
CHEMBL266094 9-BENZYL-9H-ADENINE IC50 = 160000.0 nM -
CHEMBL544491 IC50 = 121000.0 nM -