Assay Detail
Binding
CHEMBL764553
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Inhibition of rolipram binding to phosphodiesterase 4
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.49 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.07 |
| CHEMBL556179 | — | — | 1 | 8.85 |
| CHEMBL554636 | — | — | 1 | 8.85 |
| CHEMBL553502 | — | — | 1 | 8.82 |
| CHEMBL544766 | — | — | 1 | 8.77 |
| CHEMBL542299 | — | — | 1 | 8.74 |
| CHEMBL543016 | — | — | 1 | 8.52 |
| CHEMBL542650 | — | — | 1 | 8.51 |
| CHEMBL536568 | — | — | 1 | 8.46 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.42 |
| CHEMBL545700 | — | — | 1 | 8.27 |
| CHEMBL539265 | — | — | 1 | 8.19 |
| CHEMBL553278 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL556179 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL554636 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL553502 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL544766 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL542299 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL543016 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL542650 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL536568 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL63 | ROLIPRAM | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL545700 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL539265 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL553278 | — | Ki | = | 120.0 | nM | 6.92 |