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Assay Detail

CHEMBL764564

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Rolipram binding to PDE4
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors.
Regan J, Bruno J, McGarry D, Poli G, Hanney B, Bower S, Travis J, Sweeney D, Miller B, Souness J, Djuric S.
Bioorg Med Chem Lett (1998) 8 : 2737 -2742
PubMed 9873613 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 7.20 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL93823 1 9.00
CHEMBL42126 PICLAMILAST 2.0 1 9.00
CHEMBL329556 1 7.62
CHEMBL94009 1 7.62
CHEMBL449708 1 7.60
CHEMBL94255 1 7.35
CHEMBL330055 1 7.25
CHEMBL89931 1 7.12
CHEMBL329365 1 6.47
CHEMBL329155 1 6.27
CHEMBL93327 1 6.15
CHEMBL329023 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL93823 Ki = 1.0 nM 9.00
CHEMBL42126 PICLAMILAST Ki = 1.0 nM 9.00
CHEMBL329556 Ki = 24.0 nM 7.62
CHEMBL94009 Ki = 24.0 nM 7.62
CHEMBL449708 Ki = 25.0 nM 7.60
CHEMBL94255 Ki = 45.0 nM 7.35
CHEMBL330055 Ki = 56.0 nM 7.25
CHEMBL89931 Ki = 75.0 nM 7.12
CHEMBL329365 Ki = 340.0 nM 6.47
CHEMBL329155 Ki = 540.0 nM 6.27
CHEMBL93327 Ki = 712.0 nM 6.15
CHEMBL329023 Ki = 10000.0 nM 5.00