Assay Detail
Binding
CHEMBL764570
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Inhibition of Protein kinase C beta 1
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.27 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106384 | — | — | 1 | 8.00 |
| CHEMBL103055 | — | — | 1 | 7.85 |
| CHEMBL105477 | — | — | 1 | 7.57 |
| CHEMBL103506 | — | — | 1 | 7.51 |
| CHEMBL103628 | — | — | 1 | 7.51 |
| CHEMBL106061 | — | — | 1 | 7.33 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.20 |
| CHEMBL321529 | — | — | 1 | 7.17 |
| CHEMBL321315 | — | — | 1 | 7.14 |
| CHEMBL105620 | — | — | 1 | 6.85 |
| CHEMBL319265 | — | — | 1 | 6.60 |
| CHEMBL103421 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106384 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL103055 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL105477 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL103506 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL103628 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL106061 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL321529 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL321315 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL105620 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL319265 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL103421 | — | IC50 | = | 300.0 | nM | 6.52 |