Assay Detail
Binding
CHEMBL764729
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its inhibitory potency against plasmin
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 59 | 4.64 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432172 | — | — | 1 | 5.52 |
| CHEMBL310760 | — | — | 1 | 4.22 |
| CHEMBL448786 | — | — | 1 | 4.18 |
| CHEMBL78173 | — | — | 1 | - |
| CHEMBL75624 | — | — | 1 | - |
| CHEMBL80878 | — | — | 1 | - |
| CHEMBL311482 | — | — | 1 | - |
| CHEMBL75972 | — | — | 1 | - |
| CHEMBL307927 | — | — | 1 | - |
| CHEMBL309395 | — | — | 1 | - |
| CHEMBL298256 | — | — | 1 | - |
| CHEMBL75635 | — | — | 1 | - |
| CHEMBL309830 | — | — | 1 | - |
| CHEMBL43463 | — | — | 1 | - |
| CHEMBL306258 | — | — | 1 | - |
| CHEMBL312463 | — | — | 1 | - |
| CHEMBL79655 | — | — | 1 | - |
| CHEMBL307427 | — | — | 1 | - |
| CHEMBL46809 | — | — | 1 | - |
| CHEMBL307479 | — | — | 1 | - |
| CHEMBL306620 | — | — | 1 | - |
| CHEMBL78283 | — | — | 1 | - |
| CHEMBL308764 | — | — | 1 | - |
| CHEMBL77007 | — | — | 1 | - |
| CHEMBL77326 | — | — | 1 | - |
| CHEMBL77074 | — | — | 1 | - |
| CHEMBL76070 | — | — | 1 | - |
| CHEMBL311655 | — | — | 1 | - |
| CHEMBL76424 | — | — | 1 | - |
| CHEMBL42900 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432172 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL310760 | — | Ki | = | 60000.0 | nM | 4.22 |
| CHEMBL448786 | — | Ki | = | 66000.0 | nM | 4.18 |
| CHEMBL80878 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL77183 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL75624 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL78173 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL310412 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL80502 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL77182 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL307637 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL80930 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL263557 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL431969 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL75679 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL308074 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL308632 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL76796 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL308763 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL77998 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL77043 | — | Ki | = | 632000.0 | nM | - |
| CHEMBL312023 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL307597 | — | Ki | = | 570000.0 | nM | - |
| CHEMBL76967 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL307374 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL406737 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL46809 | — | Ki | = | 494000.0 | nM | - |
| CHEMBL42900 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL76424 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL311655 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL76070 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL77074 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL77326 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL77007 | — | Ki | = | 700000.0 | nM | - |
| CHEMBL308764 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL78283 | — | Ki | = | 576000.0 | nM | - |
| CHEMBL306620 | — | Ki | = | 700000.0 | nM | - |
| CHEMBL307479 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL311482 | — | Ki | = | 155000.0 | nM | - |
| CHEMBL307427 | — | Ki | = | 316000.0 | nM | - |
| CHEMBL79655 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL312463 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL306258 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL43463 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL309830 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL75635 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL298256 | — | Ki | = | 134000.0 | nM | - |
| CHEMBL309395 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL307927 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL75972 | — | Ki | > | 1000000.0 | nM | - |