Assay Detail
Binding
CHEMBL764743
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Inhibition of Phosphodiesterase 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.55 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1339 | VARDENAFIL HYDROCHLORIDE | 4.0 | 1 | 6.75 |
| CHEMBL168949 | — | — | 1 | 6.52 |
| CHEMBL352722 | — | — | 1 | 6.52 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1339 | VARDENAFIL HYDROCHLORIDE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL168949 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL352722 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 400.0 | nM | 6.40 |