Assay Detail
Binding
CHEMBL764745
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Inhibition of Prostaglandin G/H synthase 2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
From indomethacin to a selective COX-2 inhibitor: Development of indolalkanoic acids as potent and selective cyclooxygenase-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.99 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352174 | — | — | 1 | 8.70 |
| CHEMBL159740 | — | — | 1 | 8.52 |
| CHEMBL162202 | — | — | 1 | 8.52 |
| CHEMBL349248 | — | — | 1 | 8.40 |
| CHEMBL162743 | — | — | 1 | 8.40 |
| CHEMBL349600 | — | — | 1 | 8.22 |
| CHEMBL320140 | — | — | 1 | 8.05 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.00 |
| CHEMBL162776 | — | — | 1 | 7.80 |
| CHEMBL162324 | — | — | 1 | 7.70 |
| CHEMBL164194 | — | — | 1 | 7.22 |
| CHEMBL159315 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352174 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL159740 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL162202 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL349248 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL162743 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL349600 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL320140 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL162776 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL162324 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL164194 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL159315 | — | IC50 | = | 500.0 | nM | 6.30 |