Assay Detail
Binding
CHEMBL764770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Platelet-derived growth factor receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2095189) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.84 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322028 | — | — | 1 | 8.40 |
| CHEMBL105364 | — | — | 1 | 8.22 |
| CHEMBL104087 | — | — | 1 | 7.38 |
| CHEMBL108216 | — | — | 1 | 6.47 |
| CHEMBL66643 | — | — | 1 | 6.34 |
| CHEMBL105305 | — | — | 1 | 5.80 |
| CHEMBL322428 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322028 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL105364 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL104087 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL108216 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL66643 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL105305 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL322428 | — | IC50 | = | 5100.0 | nM | 5.29 |