Assay Detail
Binding
CHEMBL764773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Platelet-derived growth factor receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2095189) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Potent quinoxaline-based inhibitors of PDGF receptor tyrosine kinase activity. Part 1: SAR exploration and effective bioisosteric replacement of a phenyl substituent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.92 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107677 | — | — | 1 | 7.39 |
| CHEMBL104477 | — | — | 1 | 7.19 |
| CHEMBL104466 | — | — | 1 | 7.12 |
| CHEMBL105066 | — | — | 1 | 7.04 |
| CHEMBL104473 | — | — | 1 | 7.02 |
| CHEMBL107402 | — | — | 1 | 6.91 |
| CHEMBL104616 | — | — | 1 | 6.89 |
| CHEMBL319435 | — | — | 1 | 6.80 |
| CHEMBL106614 | — | — | 1 | 6.65 |
| CHEMBL104798 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107677 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL104477 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL104466 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL105066 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL104473 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL107402 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL104616 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL319435 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL106614 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL104798 | — | IC50 | = | 601.0 | nM | 6.22 |