Assay Detail
Binding
CHEMBL764837
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Inhibitory activity against phosphodiesterase-3 (PDE3) isolated from canine heart
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
1,7- and 2,7-naphthyridine derivatives as potent and highly specific PDE5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.28 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541823 | — | — | 1 | 5.28 |
| CHEMBL540294 | — | — | 1 | - |
| CHEMBL540031 | — | — | 1 | - |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | - |
| CHEMBL77971 | — | — | 1 | - |
| CHEMBL542410 | — | — | 1 | - |
| CHEMBL539783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541823 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL540294 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL540031 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192 | SILDENAFIL | IC50 | > | 100000.0 | nM | - |
| CHEMBL77971 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL542410 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL539783 | — | IC50 | > | 100000.0 | nM | - |