Assay Detail
Binding
CHEMBL764847
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Inhibition of rolipram binding to Phosphodiesterase 4
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.35 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 8.82 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 8.80 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL63 | ROLIPRAM | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL511115 | CILOMILAST | Ki | = | 38.0 | nM | 7.42 |