Assay Detail
Binding
CHEMBL764859
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Inhibition of human placental aldose reductase (HPAR) activity with glyceraldehyde as substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.39 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19187 | — | — | 1 | 7.52 |
| CHEMBL19427 | — | — | 1 | 7.30 |
| CHEMBL19711 | — | — | 1 | 7.00 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.92 |
| CHEMBL19744 | — | — | 1 | 6.89 |
| CHEMBL279878 | — | — | 1 | 6.82 |
| CHEMBL19495 | — | — | 1 | 6.75 |
| CHEMBL19532 | — | — | 1 | 6.72 |
| CHEMBL19316 | — | — | 1 | 6.66 |
| CHEMBL274727 | — | — | 1 | 6.64 |
| CHEMBL18854 | — | — | 1 | 6.64 |
| CHEMBL443492 | — | — | 1 | 6.60 |
| CHEMBL19502 | — | — | 1 | 6.57 |
| CHEMBL19649 | — | — | 1 | 6.57 |
| CHEMBL18865 | — | — | 1 | 6.42 |
| CHEMBL19781 | — | — | 1 | 6.33 |
| CHEMBL440790 | — | — | 1 | 6.24 |
| CHEMBL429059 | — | — | 1 | 6.24 |
| CHEMBL278584 | — | — | 1 | 6.21 |
| CHEMBL19885 | — | — | 1 | 6.21 |
| CHEMBL277427 | — | — | 1 | 6.21 |
| CHEMBL19789 | — | — | 1 | 5.92 |
| CHEMBL275868 | — | — | 1 | 5.90 |
| CHEMBL278565 | — | — | 1 | 5.41 |
| CHEMBL280357 | — | — | 1 | 5.35 |
| CHEMBL19392 | — | — | 1 | 5.25 |
| CHEMBL19746 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19187 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL19427 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL19711 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL266497 | SORBINIL | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL19744 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL279878 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL19495 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL19532 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL19316 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL274727 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL18854 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL443492 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL19502 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL19649 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL18865 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL19781 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL440790 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL429059 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL278584 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL19885 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL277427 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL19789 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL275868 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL278565 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL280357 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL19392 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL19746 | — | IC50 | = | 7470.0 | nM | 5.13 |