Assay Detail
Binding
CHEMBL764860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.91 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | 2.0 | 2 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL10372 | ZOPOLRESTAT | IC50 | = | 81.0 | nM | 7.09 |