Assay Detail
Binding
CHEMBL764924
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against HIV protease
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis, and evaluation of tetrahydropyrimidinones as an example of a general approach to nonpeptide HIV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.93 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284942 | — | — | 1 | 10.74 |
| CHEMBL284340 | — | — | 1 | 10.06 |
| CHEMBL284136 | — | — | 1 | 9.92 |
| CHEMBL286390 | — | — | 1 | 9.60 |
| CHEMBL289762 | — | — | 1 | 9.52 |
| CHEMBL285871 | — | — | 1 | 9.31 |
| CHEMBL289907 | — | — | 1 | 8.85 |
| CHEMBL297493 | — | — | 1 | 8.82 |
| CHEMBL36862 | — | — | 1 | 8.77 |
| CHEMBL49870 | — | — | 1 | 8.70 |
| CHEMBL298253 | — | — | 1 | 8.60 |
| CHEMBL36725 | — | — | 1 | 8.42 |
| CHEMBL285282 | — | — | 1 | 8.31 |
| CHEMBL39592 | — | — | 1 | 8.10 |
| CHEMBL38339 | — | — | 1 | 7.96 |
| CHEMBL39749 | — | — | 1 | 7.82 |
| CHEMBL37118 | — | — | 1 | 7.48 |
| CHEMBL297187 | — | — | 1 | 7.40 |
| CHEMBL49823 | — | — | 1 | 6.26 |
| CHEMBL298120 | — | — | 1 | 6.11 |
| CHEMBL36481 | — | — | 1 | 6.01 |
| CHEMBL296549 | — | — | 1 | 5.71 |
| CHEMBL443260 | — | — | 1 | 5.48 |
| CHEMBL297133 | — | — | 1 | 5.32 |
| CHEMBL296111 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284942 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL284340 | — | Ki | = | 0.088 | nM | 10.06 |
| CHEMBL284136 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL286390 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL289762 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL285871 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL289907 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL297493 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL36862 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL49870 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL298253 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL36725 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL285282 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL39592 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL38339 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL39749 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL37118 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL297187 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL49823 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL298120 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL36481 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL296549 | — | Ki | = | 1970.0 | nM | 5.71 |
| CHEMBL443260 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL297133 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL296111 | — | Ki | = | 8000.0 | nM | 5.10 |