Assay Detail
Binding
CHEMBL764928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards HIV protease
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-based design of novel HIV protease inhibitors: sulfonamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent non-peptidic inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.78 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78493 | — | — | 1 | 9.00 |
| CHEMBL310889 | — | — | 1 | 8.40 |
| CHEMBL80529 | — | — | 1 | 7.55 |
| CHEMBL22164 | — | — | 1 | 7.42 |
| CHEMBL78518 | — | — | 1 | 7.36 |
| CHEMBL310551 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78493 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL310889 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL80529 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL22164 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL78518 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL310551 | — | Ki | = | 110.0 | nM | 6.96 |