Assay Detail
Binding
CHEMBL764930
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Binding affinity towards HIV protease was determined
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cycloalkylpyranones and cycloalkyldihydropyrones as HIV protease inhibitors: exploring the impact of ring size on structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 8.19 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132739 | — | — | 1 | 10.74 |
| CHEMBL2111883 | — | — | 1 | 10.30 |
| CHEMBL129900 | — | — | 1 | 10.19 |
| CHEMBL415722 | — | — | 1 | 10.12 |
| CHEMBL130283 | — | — | 1 | 9.83 |
| CHEMBL133804 | — | — | 1 | 9.76 |
| CHEMBL335737 | — | — | 1 | 9.72 |
| CHEMBL336746 | — | — | 1 | 9.70 |
| CHEMBL335653 | — | — | 1 | 9.60 |
| CHEMBL132577 | — | — | 1 | 7.82 |
| CHEMBL275899 | — | — | 1 | 7.12 |
| CHEMBL297888 | — | — | 1 | 6.32 |
| CHEMBL337439 | — | — | 1 | 6.17 |
| CHEMBL292913 | — | — | 1 | 6.16 |
| CHEMBL1465 | PHENPROCOUMON | 4.0 | 1 | 6.10 |
| CHEMBL57231 | — | — | 1 | 5.96 |
| CHEMBL423528 | — | — | 1 | 5.92 |
| CHEMBL133951 | — | — | 1 | 5.82 |
| CHEMBL16316 | — | — | 1 | - |
| CHEMBL134038 | — | — | 1 | - |
| CHEMBL422614 | — | — | 1 | - |
| CHEMBL132747 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132739 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL2111883 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL129900 | — | Ki | = | 0.065 | nM | 10.19 |
| CHEMBL415722 | — | Ki | = | 0.075 | nM | 10.12 |
| CHEMBL130283 | — | Ki | = | 0.147 | nM | 9.83 |
| CHEMBL133804 | — | Ki | = | 0.175 | nM | 9.76 |
| CHEMBL335737 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL336746 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL335653 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL132577 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL275899 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL297888 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL337439 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL292913 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL1465 | PHENPROCOUMON | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL57231 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL423528 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL133951 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL16316 | — | Ki | = | 0.007 | nM | - |
| CHEMBL134038 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL422614 | — | Ki | > | 1200.0 | nM | - |
| CHEMBL132747 | — | Ki | > | 2000.0 | nM | - |