Assay Detail
Binding
CHEMBL764942
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In vitro binding at EP3 human prostaglandin receptor using [3H]PGE-2 as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.96 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL815 | DINOPROST | 4.0 | 1 | 6.96 |
| CHEMBL134546 | — | — | 1 | - |
| CHEMBL440164 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL815 | DINOPROST | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL134546 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL440164 | — | IC50 | > | 10000.0 | nM | - |