Assay Detail
Binding
CHEMBL765006
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Binding affinity against HIV-1 protease
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cyclic HIV-1 protease inhibitors derived from mannitol: synthesis, inhibitory potencies, and computational predictions of binding affinities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.94 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354502 | — | — | 1 | 9.64 |
| CHEMBL21145 | DMP-323 | — | 1 | 9.57 |
| CHEMBL171148 | — | — | 1 | 7.91 |
| CHEMBL170517 | — | — | 1 | 7.83 |
| CHEMBL130998 | — | — | 1 | 7.72 |
| CHEMBL69731 | — | — | 1 | 6.67 |
| CHEMBL355782 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354502 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL21145 | DMP-323 | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL171148 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL170517 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL130998 | — | Ki | = | 19.1 | nM | 7.72 |
| CHEMBL69731 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL355782 | — | Ki | = | 570.0 | nM | 6.24 |