Assay Detail
Functional
CHEMBL765030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [14C]aminopyrine (AP) accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Nicotinamide derivatives as a new class of gastric H+/K(+)-ATPase inhibitors. 1. Synthesis and structure-activity relationships of N-substituted 2-(benzhydryl- and benzylsulfinyl)nicotinamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.71 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | 4.0 | 1 | 6.43 |
| CHEMBL110960 | — | — | 1 | 6.40 |
| CHEMBL108610 | — | — | 1 | 6.35 |
| CHEMBL108536 | — | — | 1 | 6.34 |
| CHEMBL323189 | — | — | 1 | 6.23 |
| CHEMBL108285 | — | — | 1 | 5.92 |
| CHEMBL111351 | — | — | 1 | 5.82 |
| CHEMBL325803 | — | — | 1 | 5.77 |
| CHEMBL109629 | — | — | 1 | 5.72 |
| CHEMBL322809 | — | — | 1 | 4.78 |
| CHEMBL111282 | — | — | 1 | 4.58 |
| CHEMBL320710 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1503 | OMEPRAZOLE | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL110960 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL108610 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL108536 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL323189 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL108285 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL111351 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL325803 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL109629 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL322809 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL111282 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL320710 | — | IC50 | = | 59000.0 | nM | 4.23 |