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Assay Detail

CHEMBL765171

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Binding
Inhibitory activity against HIV protease
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 protease (CHEMBL243) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Nonsymmetric P2/P2' cyclic urea HIV protease inhibitors. Structure-activity relationship, bioavailability, and resistance profile of monoindazole-substituted P2 analogues.
De Lucca GV, Kim UT, Liang J, Cordova B, Klabe RM, Garber S, Bacheler LT, Lam GN, Wright MR, Logue KA, Erickson-Viitanen S, Ko SS, Trainor GL.
J Med Chem (1998) 41 : 2411 -2423
PubMed 9632373 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 53 10.30 10.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL291677 — — 1 10.85
CHEMBL311474 — — 1 10.80
CHEMBL312796 — — 1 10.80
CHEMBL284942 — — 1 10.74
CHEMBL420944 — — 1 10.74
CHEMBL79149 — — 1 10.74
CHEMBL78671 — — 1 10.74
CHEMBL312366 — — 1 10.68
CHEMBL312349 — — 1 10.66
CHEMBL288254 — — 1 10.64
CHEMBL11266 — — 1 10.62
CHEMBL80182 — — 1 10.60
CHEMBL78504 — — 1 10.57
CHEMBL57375 — — 1 10.57
CHEMBL312659 — — 1 10.55
CHEMBL310125 — — 1 10.54
CHEMBL82422 — — 1 10.52
CHEMBL311298 — — 1 10.52
CHEMBL311944 — — 1 10.47
CHEMBL312674 — — 1 10.44
CHEMBL312672 — — 1 10.44
CHEMBL311724 — — 1 10.41
CHEMBL311499 — — 1 10.41
CHEMBL312030 — — 1 10.40
CHEMBL311515 — — 1 10.39
CHEMBL81383 — — 1 10.37
CHEMBL78674 — — 1 10.35
CHEMBL433136 — — 1 10.35
CHEMBL81514 — — 1 10.34
CHEMBL310691 — — 1 10.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL291677 — Ki = 0.014 nM 10.85
CHEMBL311474 — Ki = 0.016 nM 10.80
CHEMBL312796 — Ki = 0.016 nM 10.80
CHEMBL284942 — Ki = 0.018 nM 10.74
CHEMBL420944 — Ki = 0.018 nM 10.74
CHEMBL79149 — Ki = 0.018 nM 10.74
CHEMBL78671 — Ki = 0.018 nM 10.74
CHEMBL312366 — Ki = 0.021 nM 10.68
CHEMBL312349 — Ki = 0.022 nM 10.66
CHEMBL288254 — Ki = 0.023 nM 10.64
CHEMBL11266 — Ki = 0.024 nM 10.62
CHEMBL80182 — Ki = 0.025 nM 10.60
CHEMBL78504 — Ki = 0.027 nM 10.57
CHEMBL57375 — Ki = 0.027 nM 10.57
CHEMBL312659 — Ki = 0.028 nM 10.55
CHEMBL310125 — Ki = 0.029 nM 10.54
CHEMBL82422 — Ki = 0.03 nM 10.52
CHEMBL311298 — Ki = 0.03 nM 10.52
CHEMBL311944 — Ki = 0.034 nM 10.47
CHEMBL312674 — Ki = 0.036 nM 10.44
CHEMBL312672 — Ki = 0.036 nM 10.44
CHEMBL311724 — Ki = 0.039 nM 10.41
CHEMBL311499 — Ki = 0.039 nM 10.41
CHEMBL312030 — Ki = 0.04 nM 10.40
CHEMBL311515 — Ki = 0.041 nM 10.39
CHEMBL81383 — Ki = 0.043 nM 10.37
CHEMBL433136 — Ki = 0.045 nM 10.35
CHEMBL78674 — Ki = 0.045 nM 10.35
CHEMBL81514 — Ki = 0.046 nM 10.34
CHEMBL310691 — Ki = 0.048 nM 10.32
CHEMBL310124 — Ki = 0.049 nM 10.31
CHEMBL312358 — Ki = 0.05 nM 10.30
CHEMBL310677 — Ki = 0.05 nM 10.30
CHEMBL82363 — Ki = 0.051 nM 10.29
CHEMBL312382 — Ki = 0.054 nM 10.27
CHEMBL311267 — Ki = 0.059 nM 10.23
CHEMBL79023 — Ki = 0.059 nM 10.23
CHEMBL310973 — Ki = 0.063 nM 10.20
CHEMBL82606 — Ki = 0.066 nM 10.18
CHEMBL311079 — Ki = 0.073 nM 10.14
CHEMBL309238 — Ki = 0.081 nM 10.09
CHEMBL284340 — Ki = 0.088 nM 10.06
CHEMBL78949 — Ki = 0.11 nM 9.96
CHEMBL309557 — Ki = 0.11 nM 9.96
CHEMBL312562 — Ki = 0.17 nM 9.77
CHEMBL81396 — Ki = 0.21 nM 9.68
CHEMBL311773 — Ki = 0.23 nM 9.64
CHEMBL312054 — Ki = 0.23 nM 9.64
CHEMBL223824 MOZENAVIR Ki = 0.28 nM 9.55
CHEMBL33647 — Ki = 0.31 nM 9.51