Assay Detail
Binding
CHEMBL765172
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Inhibitory activity against HIV-1 Protease
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.62 | 10.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366386 | — | — | 1 | 10.21 |
| CHEMBL130078 | — | — | 1 | 10.15 |
| CHEMBL338844 | — | — | 1 | 9.66 |
| CHEMBL129862 | — | — | 1 | 9.66 |
| CHEMBL21145 | DMP-323 | — | 1 | 9.64 |
| CHEMBL340958 | — | — | 1 | 9.31 |
| CHEMBL49870 | — | — | 1 | 8.70 |
| CHEMBL443030 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366386 | — | Ki | = | 0.062 | nM | 10.21 |
| CHEMBL130078 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL338844 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL129862 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL21145 | DMP-323 | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL340958 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL49870 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL443030 | — | Ki | = | 0.005 | nM | - |