Assay Detail
Binding
CHEMBL765174
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Inhibitory activity against HIV-1 protease
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multidrug resistant HIV-1 strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 9.72 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299578 | — | — | 1 | 10.00 |
| CHEMBL49002 | — | — | 1 | 9.92 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.72 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.55 |
| CHEMBL50945 | — | — | 1 | 9.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299578 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL49002 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL50945 | — | Ki | = | 0.38 | nM | 9.42 |