Assay Detail
Binding
CHEMBL765177
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Inhibitory activity was evaluated against HIV protease
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Potent cyclic urea HIV protease inhibitors with benzofused heterocycles as P2/P2 groups
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.75 | 10.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78671 | — | — | 1 | 10.74 |
| CHEMBL320005 | — | — | 1 | 10.74 |
| CHEMBL99174 | — | — | 1 | 10.05 |
| CHEMBL316732 | — | — | 1 | 9.85 |
| CHEMBL98826 | — | — | 1 | 9.74 |
| CHEMBL316939 | — | — | 1 | 9.72 |
| CHEMBL441350 | — | — | 1 | 9.70 |
| CHEMBL21145 | DMP-323 | — | 1 | 9.51 |
| CHEMBL97836 | — | — | 1 | 9.09 |
| CHEMBL98785 | — | — | 1 | 9.04 |
| CHEMBL99013 | — | — | 1 | 8.89 |
| CHEMBL330619 | — | — | 1 | 8.47 |
| CHEMBL99033 | — | — | 1 | 8.41 |
| CHEMBL330405 | — | — | 1 | 8.32 |
| CHEMBL329711 | — | — | 1 | 8.24 |
| CHEMBL95271 | — | — | 1 | 8.24 |
| CHEMBL317976 | — | — | 1 | 8.21 |
| CHEMBL320219 | — | — | 1 | 7.96 |
| CHEMBL318851 | — | — | 1 | 7.55 |
| CHEMBL319509 | — | — | 1 | 6.89 |
| CHEMBL330404 | — | — | 1 | 6.72 |
| CHEMBL99032 | — | — | 1 | 6.31 |
| CHEMBL316681 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78671 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL320005 | — | Ki | = | 0.018 | nM | 10.74 |
| CHEMBL99174 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL316732 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL98826 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL316939 | — | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL441350 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL21145 | DMP-323 | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL97836 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL98785 | — | Ki | = | 0.91 | nM | 9.04 |
| CHEMBL99013 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL330619 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL99033 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL330405 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL329711 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL95271 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL317976 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL320219 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL318851 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL319509 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL330404 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL99032 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL316681 | — | Ki | < | 0.01 | nM | - |