Assay Detail
Binding
CHEMBL765178
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Inhibitory concentration against HIV-1 protease
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of potent C(2)-symmetric diol-based HIV-1 protease inhibitors: effects of fluoro substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.75 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.64 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 9.64 |
| CHEMBL105459 | — | — | 1 | 9.10 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 9.09 |
| CHEMBL107965 | — | — | 1 | 8.95 |
| CHEMBL317031 | — | — | 1 | 8.91 |
| CHEMBL320893 | — | — | 1 | 8.89 |
| CHEMBL431422 | — | — | 1 | 8.79 |
| CHEMBL322669 | — | — | 1 | 8.78 |
| CHEMBL105138 | — | — | 1 | 8.76 |
| CHEMBL317263 | — | — | 1 | 8.75 |
| CHEMBL102228 | — | — | 1 | 8.74 |
| CHEMBL322026 | — | — | 1 | 8.72 |
| CHEMBL104324 | — | — | 1 | 8.70 |
| CHEMBL431648 | — | — | 1 | 8.70 |
| CHEMBL103927 | — | — | 1 | 8.70 |
| CHEMBL422961 | — | — | 1 | 8.49 |
| CHEMBL431241 | — | — | 1 | 8.48 |
| CHEMBL317236 | — | — | 1 | 8.41 |
| CHEMBL319704 | — | — | 1 | 8.40 |
| CHEMBL317690 | — | — | 1 | 8.30 |
| CHEMBL107428 | — | — | 1 | 8.27 |
| CHEMBL320936 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL584 | NELFINAVIR | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL105459 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.82 | nM | 9.09 |
| CHEMBL107965 | — | Ki | = | 1.12 | nM | 8.95 |
| CHEMBL317031 | — | Ki | = | 1.22 | nM | 8.91 |
| CHEMBL320893 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL431422 | — | Ki | = | 1.64 | nM | 8.79 |
| CHEMBL322669 | — | Ki | = | 1.65 | nM | 8.78 |
| CHEMBL105138 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL317263 | — | Ki | = | 1.79 | nM | 8.75 |
| CHEMBL102228 | — | Ki | = | 1.83 | nM | 8.74 |
| CHEMBL322026 | — | Ki | = | 1.92 | nM | 8.72 |
| CHEMBL104324 | — | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL431648 | — | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL103927 | — | Ki | = | 1.98 | nM | 8.70 |
| CHEMBL422961 | — | Ki | = | 3.26 | nM | 8.49 |
| CHEMBL431241 | — | Ki | = | 3.29 | nM | 8.48 |
| CHEMBL317236 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL319704 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL317690 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL107428 | — | Ki | = | 5.39 | nM | 8.27 |
| CHEMBL320936 | — | Ki | = | 7.13 | nM | 8.15 |